(Hemophilia A—Factor VIII Deficiency; Classic Hemophilia; Hemophilia B—Factor IX Deficiency; Christmas Disease)
- Hemophilia A (classic hemophilia)—accounts for 80% of all hemophilia (1 in 5,000 males), caused by too little factor VIII
- Hemophilia B (Christmas disease)—occurs in 1 in 25,000 males, caused by too little factor IX
|Genetic Outcome Possibilities|
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- Family members with hemophilia
- Family history of bleeding disorders
- Sex: male
- Hot, swollen, sore, stiff, and/or deformed joints
- Bleeding into muscles
- Bleeding into the intestinal tract
- Bloody stools
- Bloody urine
- Difficulty stopping bleeding after minor cuts or bumps
- Heavy bleeding even after simple surgical or dental procedures
- Tests of bleeding time
- Blood tests to measure the amounts of clotting factors present
Blood Factor Concentrate
- Tranexamic acid
- Epsilon-aminocaproic acid
- Good dental care is important. It may decrease the risk of major dental work.
Be aware of the effect of high impact activities:
- Take extra care to protect the head from injuries.
- People with severe hemophilia should avoid activities that include a high risk of collision.
Avoid drugs that can also aggravate bleeding problems such as:
- Certain analgesics, such as nonsteroidal anti-inflammatory drugs (eg, ibuprofen )
American Society of Hematology http://www.hematology.org/
National Hemophilia Foundation http://www.hemophilia.org/
Caring for Kids http://www.caringforkids.cps.ca/
Network of Rare Blood Disorder Organizations http://www.hemophilia.ca/en/about-the-chs/collaboration/network-of-rare-blood-disorder-organizations/
Hemophilia A. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated October 23, 2012. Accessed October 24, 2012.
Hemophilia B. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated October 23, 2012. Accessed October 24, 2012.
Current Medical Diagnosis and Treatment . Lange Medical Books; 2001.
Family Practice Sourcebook . Mosby; 2000.
Ferri's Clinical Advisor . Mosby; 2000.
The Little Black Book of Primary Care . Blackwell Science; 1999.
10/24/2012 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Broderick CR, Herbert RD, Latimer J, Barnes C, Curtin JA, Mathieu E, Monagle P, Brown SA. Association between physical activity and risk of bleeding in children with hemophilia. JAMA . 2012 Oct 10;308(14):1452-9.
- Reviewer: Igor Puzanov, MD
- Review Date: 03/2013 -
- Update Date: 00/31/2013 -